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|Synthesis of new Pyridine and Fluorene based compounds Via Suzuki-Miyaura reaction: their characterization, DFT studies and evaluation of anti-bacterial, antifungal and analgesic potential
|University of Peshawar, Peshawar.
|The first chapter of dissertation is general overview which introduces Transition metals catalyzed cross coupling reactions especially Palladium catalyzed crosscoupling reactions. These have recently emerged as one of the most powerful and fundamental transformations in organic syntheses. Among the several Palladium catalyzed cross-coupling reactions, Suzuki-Miyura cross-coupling reaction has become an extremely important method for the construction of carbon-carbon bonds. The second chapter describes the synthesis of Pyridine derivatives, synthesized via Suzuki cross coupling reaction of 3, 5-Dibromopyridine with different boronic acids. Arylated Pyridines were obtained in high yields. Structures of these compounds were confirmed by 1HNMR, 13CNMR, GC-MS, FTIR, CHNS and single crystal X-Ray analysis. Mono-arylation was also observed in a compound, 3-bromo-5-(2, 5- difluorophenyl), 3b, using 1 equivalent of arylboronic acid. Regioselectivity is also studied and well characterized with help of XRD analysis. The third chapter describes the syntheses of arylated fluorenes synthesized via Suzuki cross coupling reaction of 2, 7-dibromofluorene with different boronic acids. Several trials were made to enhance yield of final products by using different catalytic systems. Extensively diversified arylated fluorenes were synthesized in relatively high yields. Structures of these compounds were confirmed by 1HNMR, 13CNMR, GC-MS, FTIR, CHNS and single crystal X-Ray analysis. Synthesized arylated fluorenes are not readily available by any other methodologies. The fourth chapter describes the experimental procedures, results and discussion and interpretation of data of synthesized compounds while chapter fifth describes the iv Crystal data of the crystalline compounds and DFT studies have been discussed in sixth chapter. The chapter seventh describes the biological activities of the synthesized compounds. These compounds were subjected to various biological activities like anti-bacterial, anti-fungal, activities. The overall biological activity screening demonstrated that majority of compounds are significantly bioactive.
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