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Title: A Drosophila Model to Unravel Functional Roles for Key Neuroendocrine Metabolic Signaling Nodes
Authors: Akram, Mehwish
Keywords: Biological & Medical Sciences
Issue Date: 2020
Publisher: University of the Punjab , Lahore
Abstract: The food choice of a living organism govern its behavior, which requires a complex interplay of internal and external cues majorly controlled by the central nervous system. It is unknown how the external environmental signals transform into internal cues. In an effort to tease out the specific central components of the pathways governing macronutrient intake, Drosophila was used as a model organism to understand the link between food and behavioral disorders. It is well documented that neuropeptide F (NPF) has an important role in controlling feeding behavior of Drosophila. In order to delineate the factors acting upstream of NPF, two neurons expressing Crustacean cardioactive peptide (CCAP) were discovered that regulate food intake in flies. Similarly, the transcription factors expressing in the central nervous system have their roles in energy homeostasis. Many of these transcription factors are involved in obesity. Studies have shown that increase in BMI is associated with mood disorders. A molecular link, which has not been established before, was discovered in the present study. In this study Ets96B was used, a Drosophila homologue for human obesity linked gene Etv5, to elaborate the molecular pathway linking BMI and mental disorders, such as bipolar disorder. Moreover, metabolism and sleep have a complex relationship, and many studies have associated disruption in sleep with metabolic syndromes in mammals like type 2 diabetes. Drosophila is a well conserved model organism, which can be used to analyze the relationship between sleep and metabolism in greater detail. I demonstrated that Drosophila can be an effective tool for high throughput drug screens for metabolic disorders.
Gov't Doc #: 20716
Appears in Collections:PhD Thesis of All Public / Private Sector Universities / DAIs.

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