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Title: Carbon Nanotubes Based Nanosensor: A Promising Tool for Pharmaceutical Analysis
Authors: Aftab, Saima
Keywords: Physical Sciences
Issue Date: 2020
Publisher: Quaid-i-Azam University, Islamabad.
Abstract: The aim of this study is to design sensitive and selective electrochemical sensing platform for drugs analysis. For achieving the desired sensitivity the glassy carbon electrode (GCE) was modified with nanomaterials possessing useful physico-chemical properties. The GCE was fabricated with multi-walled carbon nanotubes (MWCNTs), their combination with graphene/carbon quantum dots (GQDs/CQDs) and metal/metal oxide nanoparticles (NPs). Four types of electrochemical sensors designated as a) NH2fMWCNTs/GCE, b) NH2-fMWCNTs/ZnONPs/GQDs/GCE, c) CQDs/NH2fMWCNTs/AgNPs/GCE and d) NH2-fMWCNTs/TiO2NPs were developed and applied for the detection of Entacapone (ENP), Pimozide (PZ), Rilpivirne (RIL) and Nadifloxacin (NF), respectively. The modified electrodes were characterized by cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS) and scanning electron microscopy (SEM) armed with EDX analysis. Experimental conditions that could influence the electroanalytical response of the designed sensors were cautiously optimized. Moreover, new strategies for pharmaceutical analysis by the designed sensors were validated according to International Council for Harmonisation guidelines. The results showed that the NH2fMWCNT modified GCE could potentially be employed to monitor ENP with a limit of detection (LOD) of 1.45 1011 M, much better than the electrochemical sensors reported so for. The NH2fMWCNT/ZnONPs/GQDs modified GCE was found to sense PZ upto 1.02 1011 M under optimized conditions. Similarly CQDs/NH2-fMWCNT/AgNPs and NH2fMWCNT/TiO2NPs modified GCEs helped in the detection of RIL and NF with LOD values of 3.00 1011 M and 1.69 1010 M respectively. All the designed sensors were found applicable for the detection of the respective drug contents in biological samples and commercially available dosage forms. The measured content values were in good agreement with the claimed amounts. The obtained recovery results suggested antiinterference ability of the designed sensors against endogenous substances and excipients, present in the biological samples and dosage forms. The presented methodologies provide advantages for the analysis of the respective drugs in terms of selectivity, sensitivity, responsiveness, reproducibility and recovery. Moreover, the proposed methods are reliable, environmentally friendly and cost-effective.
Gov't Doc #: 20253
Appears in Collections:PhD Thesis of All Public / Private Sector Universities / DAIs.

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