Chemistry of Stem of Murraya Koenigii

Abstract

The present phytochemical investigations described the isolation of chemical constituents from the stem of indigenous plant Murraya koenigii(L.) Spreng which is commonly known as curry plant. This thesis is divided into two parts. PART A Phytochemical studies of Murraya koenigii PART B Pharmacological investigation of isolated compounds In Part A, the introduction describes biosynthesis of carbazole alkaloids, their pharmacological importance and list of previously isolated chemical constituents.In the present study, total eleven different compounds have been isolated from the stemof M. koenigii. Among these isolated compounds eightwere identified as new compounds namely, aronine (66), afifine (67), jerinine (68), ferinine (69), atinine (70), zolidine (71), osinine (72) and2-methyl-3-(1-methyl cyclohex-2-en) propanol-ol (73). Moreover,other three known compoundsmurrayanine (1), mahinimbine (3) andgrinimbine (14) were also identified during this phytochemical work. In Part Bpharmacologicalactivities namely, antifungal and antibacterial and antioxidant activities of isolated compounds have been studied. The three compound girnimbine,murayanine and afifine showed antifungal activities and murrayanine and jerinine showed antibactrial activities against the tested strains. Furthermore, murrayanine, ferinine, girimbine, afifine and jerinine exhibited positive antioxidant activity.