Please use this identifier to cite or link to this item:
Full metadata record
DC FieldValueLanguage
dc.contributor.authorARSHAD, MUHAMMAD NADEEM-
dc.description.abstractNumber of thiazine related heterocyclic compounds were synthesized using various approaches to utilize indigenously available raw materials. The syntheses of targeted molecules were afforded by the easy to handle and cost effective routes with the high possible purity and yield. Synthesis of various 1,2-benzothiazine 1,1-dioxides was accomplished via Heck reaction using ligand free palladium catalyst. It involved synthesis of halogen containing sulfonyl chloride, alkyl/aryl sulfonamide, N-alkylation with different alkenyl groups by conventional methodologies followed by improved Heck cyclization with Pd(OAc) 2 /DIPA in 1-methyl-pyrolidin-2-one or toluene. In this way, two isomeric benzothiazines (with endocyclic & exocyclic double bonds) along with seven membered thiazipene products were obtained. It was also found that endocyclic product dominates over the exocyclic isomer. In accordance with the yield, endocyclic product and thiazipines were isolated in almost equal amounts (38.3% & 37.2%). Synthesis of [Cp*Ru(η 6 -((R)-8-(Hydroxy)-2-S-oxa-2-S-phenyl-2,1- benzothiazine))]Cl for their application as catalyst in chiral synthesis is was also accomplished. Chiral 2,1-benzothiazine derivative was employed to its complexation with cyclopentadiene-Ru salt under microwave radiations. One pot synthesis of a series of N-alkyl 1, 2-benzothiazine 1, 1-dioxide derivatives was carried out from commercially available saccharine with improved yield in less time avoiding extra work-ups. Number of carboxamide derivatives were also synthesized by reacting ester with different amines. Further, methyl 4-hydroxy-2H-1,2- benzothiazine-3-carboxylate-1,1-dioxide , N-alkylated derivatives methyl 4-hydroxy-2- methyl-2H-1,2-benzothiazine-3-carboxylate 1,1-dioxide, methyl 4-hydroxy-2-ethyl-2H- 1,2-benzothiazine-3-carboxylate 1,1-dioxide & methyl 4-hydroxy-2-propyl-2H-1,2- benzothiazine-3-carboxylate 1,1-dioxide , and carboxamide derivative N-(2-bromo-4- nitrophenyl)-4-hydroxy-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide were oxidized at C-3 carbon to get corresponding alcoholic products which were found dehydrated during crystallization process in methanol.en_US
dc.description.sponsorshipHigher Education Commission, Pakistanen_US
dc.subjectNatural Sciencesen_US
dc.subjectChemistry & allied sciencesen_US
dc.titleSynthesis, X-ray Studies and Biological Evaluation of Thiazine Related Heterocyclesen_US
Appears in Collections:PhD Thesis of All Public / Private Sector Universities / DAIs.

Files in This Item:
File Description SizeFormat 
978S.pdfComplete Thesis3.81 MBAdobe PDFView/Open
978S-0.pdfTable of Contents108.52 kBAdobe PDFView/Open

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.