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dc.contributor.authorJoiya, Aqeela Shaheen-
dc.description.abstractIn the present study, an efficient and a facile synthesis of a variety of carboxylic acids [HL1-HL4] and carbaldehydes entailing azoles has been carried out via N-arylation. The synthesized carbaldehydes were further reacted with 2-hydroxybenzohydrazide to yield Schiff bases [HL5-HL8]. The di- and triorganotin(IV) derivatives (1-72) of carboxylic acids and Schiff bases have also been prepared in good yields by refluxing their sodium/triethylammonium salt and the respective organotin(IV) chlorides (in 1:1 or 1:2 ratio) in suitable dry solvents for 5-7 hours. Also a series of few other Schiff bases have been synthesized by the reaction of various carbaldehydes with 3-aminopyrazine-2-carboxylic acid [HL9-HL12] and coordinated with organotin(IV) moieties (73-108) Structural elucidations of the ligands (carboxylates & Schiff bases) and their organotin(IV) complexes [1-108] are performed by CHN, IR, multinuclear NMR and MS, confirming the ligand synthesis and ligand-metal attachment (O-Sn band). The newly synthesized compounds are also screened for antifungal, antibacterial, cytotoxic and antiurease activities. Comprehensive biological studies revealed that the synthesized compounds confirm their worth in pharmaceutical domain. .en_US
dc.description.sponsorshipHigher Education Commission Pakistanen_US
dc.publisherIslamia University, Bahawalpur.en_US
dc.subjectPhysical Sciencesen_US
dc.titleStudies on Synthesis and Characterization of Organotin (IV) Derivatives with Oxygen and Nitrogen Donor Ligandsen_US
Appears in Collections:PhD Thesis of All Public / Private Sector Universities / DAIs.

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