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|Title:||Isolation, modification, characterization, pharmaceutical applications of hydrogel from seeds of Cydonia oblanga|
|Authors:||Ashraf, Muhammad Umer|
|Publisher:||University of Sargodha, Sargodha.|
|Abstract:||Extraction of Quince hydrogel (QH) was accomplished from seeds of Cydonia oblonga M (Quince) by hot water extraction method. Characterization of QH was accomplished by using Fourier transform infrared (FTIR) spectroscopy, scanning electron microscopy (SEM) and thermogravimetic analysis (TGA). Swelling of QH was carried out in deionized water, buffer solutions of pH 1.2, 6.8 and 7.4 by using gravimetric analysis, inferring that QH showed high swelling capacity in deionized water and buffer solutions of pH 7.4 and 6.8 while minor swelling was noticed in acidic buffer of pH 1.2, indicating QH as a potential biomaterial for fabrication of targeted drug delivery. Kinetic models were also applied to the swelling data acquired from swelling studies. It was concluded that swelling of QH in deionized water and phosphate buffers of pH 6.8 and 7.4 followed second order swelling kinetics. Responsiveness of QH to concentration of electrolytes was also ascertained by carrying out swelling of QH in different molar concentrations of NaCl and KCl solutions (0.1, 0.2, 0.3, 0.4, 0.5, 1.0 and 2.0 M). The QH was deduced to be responsive to concentration of electrolytes, showing a decrease in swelling capacity with increasing molar concentration of electrolytes. Swelling deswelling (on-off) response of QH was also evaluated in water and ethanol, water and normal saline and phosphate buffer of pH 7.4 and acidic buffer of pH 1.2. When water swollen QH was immersed into saline and ethanol, deswelling of QH was noticed however, deswelling in ethanol was abrupt as compared to deswelling in saline solution. Similar swelling deswelling response was noticed in phosphate buffer of pH 7.4 and acidic buffer of pH 1.2. These findings prove QH to be stimuli sensitive biomaterial with potential to be used in developing stimuli responsive drug delivery system.|
|Gov't Doc #:||19949|
|Appears in Collections:||PhD Thesis of All Public / Private Sector Universities / DAIs.|
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